RHINO-ORBITO-CEREBRAL MUCORMYCOSIS. A RETROSPECTIVE ANALYSIS OF CLINICAL FEATURES AND TREATMENT OUTCOMES




Gata2-L359V impairs primitive and definitive hematopoiesis and blocks cell differentiation in murine chronic myelogenous leukemia model

Abstract GATA2, a key transcription factor in hematopoiesis, is frequently mutated in hematopoietic malignancies.How the GATA2 mutants contribute to hematopoiesis and malignant transformation remains largely unexplored.Here, we report that Gata2-L359V mutation impeded hematopoietic differentiation in murine embryonic and adult hematopoiesis and blo

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